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KMID : 0378019740170070886
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New Medical Journal
1974 Volume.17 No. 7 p.886 ~ p.892
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Influence of Hydrocortisone on the Metabolic Effect of Plasma Glucose and Free Fatty Acids of the Ducks to Catecholamines
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Abstract
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Influence of hydrocortisone on the metabolic effect of plasma glucose and free fatty acids to norepinephrine, epinephrine and isopropylarterenol was investigated in the ducks. The following results were obtained;
In control groups, both epinephrine and isopropylarterenol increased plasma glucose and free fatty acids levels after intravenous adminstration, but norepinephrine exerted no influence on it.
Intravenous or intraventricular administration of hydrocortisone- (1 and 3mg/kg i. v. or 0.1 and 0.3 mg/kg i. vt.) did not increased plasma glucose and free fatty acids concentrations above the pretest levels, whereas larger doses (10mg/kg;i. v. or 1mg/kg i. vt.) increased them slightly.
Intravenous or intraventricular pretreatment of hydrocortisone potentiated the metabolic effect of plasma glucose and free fatty acids to norepinephrine, epinephrine and isopropylarterenol.
From these observations, it is inferred that the mechanism of potentiation by hydrocortisone of the response to norepinephrine, epinephrine and isopropylarterenol is related to central as well as peripheral roles.
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